Hyperhomocyst(e)inemia Is a Risk Factor for Arterial Endothelial Dysfunction in Humans

  title={Hyperhomocyst(e)inemia Is a Risk Factor for Arterial Endothelial Dysfunction in Humans},
  author={Kam Sang Woo and Ping Chook and Yvette I. Lolin and Ada S Cheung and Lindy L T Chan and Yuan Yuan Sun and John Elsby Sanderson and Con Metreweli and David S Celermajer},
  volume={96 8},
BACKGROUND Hyperhomocyst(e)inemia is associated with premature peripheral vascular, cerebrovascular, and coronary artery disease. Because homocysteine has been found to be damaging to endothelial cells in animal and cell culture studies, we evaluated the association between hyperhomocysteinemia and arterial endothelial dysfunction (a marker of early atherosclerosis) in asymptomatic adult subjects. METHODS AND RESULTS Using high-resolution ultrasound, we measured endothelium-dependent flow… CONTINUE READING
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