Hypergravity modulates vitamin D receptor target gene mRNA expression in mice.

  title={Hypergravity modulates vitamin D receptor target gene mRNA expression in mice.},
  author={Michiyasu Ishizawa and Ken-ichi Iwasaki and Shigeaki Kato and Makoto Makishima},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={297 3},
The possibility of pathological calcium metabolism is a critical health concern introduced by long-term space travel. Because vitamin D plays an important role in calcium homeostasis, we evaluated the effects of hypergravity on the expression of genes involved in vitamin D and calcium metabolism in ICR mice. When exposed to 2G hypergravity for 2 days, the mRNA expression of renal 25-hydroxyvitamin D 24-hydroxylase (Cyp24a1) was increased and that of 25-hydroxyvitamin D 1alpha-hydroxylase… 

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