Hyperglycosylated human chorionic gonadotropin does not increase progesterone production by luteinized granulosa cells.

@article{Crochet2012HyperglycosylatedHC,
  title={Hyperglycosylated human chorionic gonadotropin does not increase progesterone production by luteinized granulosa cells.},
  author={John R Crochet and Anish A Shah and David W. Schomberg and Thomas M. Price},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 9},
  pages={E1741-4}
}
CONTEXT Trophoblast-derived human chorionic gonadotropin (hCG) promotes corpus luteum progesterone (P4) production, and wide ranges of serum P4 levels are noted in various pregnancy outcomes, despite similar hCG concentrations. There are five unique biologically active hCG variants in human pregnancy urine, and previous studies of P4 production in response to hCG have used only preparations containing all isoforms. Understanding exactly which hCG variant is primarily responsible for stimulating… CONTINUE READING

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