Hyperglycemic athymic nude mice: factors affecting in vitro insulin secretion.

  title={Hyperglycemic athymic nude mice: factors affecting in vitro insulin secretion.},
  author={Adina Zeidler and Peter G. Edwards and Jos{\'e} Goldman and S. S. Kort and Woerner P. Meehan and Seymour R. Levin},
  journal={The American journal of physiology},
  volume={263 6 Pt 1},
The strain of athymic nude male mice (ANM) developed at the University of Southern California (USC) exhibits spontaneous hyperglycemia and relative hypoinsulinemia in vivo. To investigate factors that influence insulin secretion in this animal model of non-insulin-dependent diabetes mellitus, we utilized the isolated perfused mouse pancreas of the ANM-USC and control BALB/c mice. We compared in vitro glucose-induced insulin secretion in ANM-USC and control mice, inhibition of secretion by… CONTINUE READING

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