Hyperglycemia to nephropathy via transforming growth factor beta.

@article{Garud2014HyperglycemiaTN,
  title={Hyperglycemia to nephropathy via transforming growth factor beta.},
  author={Mayuresh Sudamrao Garud and Yogesh R. Kulkarni},
  journal={Current diabetes reviews},
  year={2014},
  volume={10 3},
  pages={
          182-9
        }
}
Nephropathy is one of the major complications of diabetes which further directs to end stage renal disease. Extensive work has been done to find out the mechanisms involved in pathogenesis of the DN. Now, many researchers have been convinced that almost all of the molecular mediators and intracellular signaling pathways involved in progression of diabetic nephropathy have involvement in transforming growth factor beta (TGF- β) at some stage. In DN, hyperglycemia causes increase in the… CONTINUE READING
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