Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor.

@article{Xiang2015HyperglycemiaRO,
  title={Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor.},
  author={Yaozu Xiang and Jijun Cheng and Dandan Wang and Xiaoyue Hu and Hong Zhang and Jeremiah Stitham and Gourg Atteya and Jing Du and Wai Ho Tang and Seung Hee Lee and Kristen L. Leslie and Geralyn R. Spollett and Zejian Liu and Erica L. Herzog and Raimund I. Herzog and Jun Lu and Kathleen A. Martin and John Hwa},
  journal={Blood},
  year={2015},
  volume={125 22},
  pages={3377-87}
}
An elevated level of von Willebrand factor (VWF) in diabetic patients is associated with increased risk of thrombotic cardiovascular events. The underlying mechanism of how VWF expression is upregulated in diabetes mellitus is poorly understood. We now report that hyperglycemia-induced repression of microRNA-24 (miR-24) increases VWF expression and secretion in diabetes mellitus. In diabetic patients and diabetic mouse models (streptozotocin/high-fat diet-induced and db/db mice), miR-24 is… CONTINUE READING
18 Citations
65 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Similar Papers

Loading similar papers…