Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells.

  title={Hyperglycemia reduces survival and impairs function of circulating blood-derived progenitor cells.},
  author={Nicolle Kraenkel and Volker Adams and Axel Linke and Stephan Gielen and Sandra Erbs and Karsten Lenk and Gerhard A. Schuler and Rainer Hambrecht},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={25 4},
OBJECTIVE Function and availability of circulating progenitor cells (CPC) have been shown to be impaired in patients with diabetes mellitus (DM). Therefore, the aim of the present study was to analyze possible mechanisms leading to the reduction of CPC amount and function. METHODS AND RESULTS Peripheral blood mononuclear cells (MNCs) of healthy donors (n=15) were cultivated under hyperglycemia (HG) conditions (12 mmol/L D-Glucose) or in osmotic control medium (Con) (5 mmol/L D-Glucose plus 7… CONTINUE READING

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