Hyperglycemia reduces mitochondrial content and glucose transporter expression in mouse embryos developing in vitro.

Abstract

The objective of this research was to examine the effects of high concentrations of glucose on mouse embryos developing in vitro by studying embryo viability, mitochondrial content and expression of glucose transporters. Addition of 55 mM glucose to the culture medium of two-cell stage embryos significantly reduced the formation of morulae and blastocysts… (More)

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