Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain.

Abstract

Increased permeability to albumin is a well-known feature of diabetic microvasculature and a negative prognostic factor of vascular complications. The mechanisms responsible for loss of the physiological albumin barrier in diabetic organs remain only partially understood. We have recently demonstrated that the protease mu-calpain is activated in… (More)

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