Hyperglycemia induced by glucose infusion causes hepatic oxidative stress and systemic inflammation, but not STAT3 or MAP kinase activation in liver in rats.

@article{Ling2003HyperglycemiaIB,
  title={Hyperglycemia induced by glucose infusion causes hepatic oxidative stress and systemic inflammation, but not STAT3 or MAP kinase activation in liver in rats.},
  author={P R Ling and Claudia Anna M{\"u}ller and Robert D. J. Smith and Bruce Ryan Bistrian},
  journal={Metabolism: clinical and experimental},
  year={2003},
  volume={52 7},
  pages={868-74}
}
The purpose of this study was to determine the effects of acute hyperglycemia induced by glucose infusion on oxidative stress, systemic inflammation, and several key signal intermediates in liver for the systemic inflammatory response in nonstressed rats. Rats received saline or glucose infusion (hyperglycemic clamp) for 3 hours. Rats without catheter insertion were included as an additional control for observing the effects of surgical stress. Levels of malondialdehyde (MDA) and total… CONTINUE READING