Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

@article{Donath1999HyperglycemiainducedBA,
  title={Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.},
  author={Marc Yves Donath and David J. Gross and Erol Cerasi and Nurit Kaiser},
  journal={Diabetes},
  year={1999},
  volume={48 4},
  pages={738-44}
}
The gerbil Psammomys obesus develops nutrition-dependent diabetes associated with moderate obesity. The disease is characterized by initial hyperinsulinemia, progressing to hypoinsulinemia associated with depleted pancreatic insulin stores. The contribution of changes in beta-cell turnover to insulin deficiency was investigated in vivo during transition to overt diabetes. Normo glycemic diabetes-prone P. obesus animals who were given a high-calorie diet developed hyperglycemia within 4 days… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 167 extracted citations

Similar Papers

Loading similar papers…