Hyperglycemia enhances excessive superoxide anion radical generation, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats.

@article{Tsuruta2010HyperglycemiaEE,
  title={Hyperglycemia enhances excessive superoxide anion radical generation, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats.},
  author={Ryosuke Tsuruta and Motoki Fujita and Takeru Ono and Yoichi Koda and Yasutaka Koga and Takahiro Yamamoto and Masahiro Nanba and Masaki Shitara and Shunji Kasaoka and Ikuro Maruyama and Makoto Yuasa and Tsuyoshi Maekawa},
  journal={Brain research},
  year={2010},
  volume={1309},
  pages={155-63}
}
The aim of this study was to confirm the effect of acute hyperglycemia on the superoxide anion radical (O(2)(-)) generation, using a novel electrochemical O(2)(-) sensor in forebrain ischemia/reperfusion rats. Fourteen male Wistar rats were allocated to a normoglycemia group (n= 7) and a hyperglycemia group (n=7). Hyperglycemia was induced by intravenous infusion of glucose solution. Forebrain ischemia was induced by bilateral common carotid arteries occlusion with hemorrhagic hypotension for… CONTINUE READING
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