Hyperglycemia enhances angiotensin II-induced janus-activated kinase/STAT signaling in vascular smooth muscle cells.

@article{Amiri1999HyperglycemiaEA,
  title={Hyperglycemia enhances angiotensin II-induced janus-activated kinase/STAT signaling in vascular smooth muscle cells.},
  author={Farhad Amiri and Virginia J. Venema and Xiaodan Wang and Hong Ju and R. Venema and Mario B. Marrero},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 45},
  pages={32382-6}
}
We have shown previously that angiotensin II (Ang II) activates the janus-activated kinase (JAK)/signal transducers and activators of transcription (STAT) pathway in vascular smooth muscle cells (VSMCs) and that activation of the JAK/STAT pathway is required for Ang II induction of VSMC proliferation. In the present study, we examined the effects of hyperglycemia (HG) on Ang II-induced JAK/STAT signaling events in cultured VSMCs. HG increases Ang II-induced JAK2 tyrosine phosphorylation and… CONTINUE READING
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