Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ.

@article{Haefliger2013HyperglycemiaDC,
  title={Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ.},
  author={J. A. Haefliger and Françoise Rohner-Jeanrenaud and Doroth{\'e}e Caille and Anne Charollais and Paolo Meda and Florent Allagnat},
  journal={Journal of molecular endocrinology},
  year={2013},
  volume={51 1},
  pages={49-58}
}
Channels formed by the gap junction protein Connexin36 (CX36) contribute to the proper control of insulin secretion. We previously demonstrated that chronic exposure to glucose decreases Cx36 levels in insulin-secreting cells in vitro. Here, we investigated whether hyperglycemia also regulates Cx36 in vivo. Using a model of continuous glucose infusion in… CONTINUE READING