Hyperglycemia and hypoxia are interrelated in their teratogenic mechanism: studies on cultured rat embryos.

@article{Ornoy2010HyperglycemiaAH,
  title={Hyperglycemia and hypoxia are interrelated in their teratogenic mechanism: studies on cultured rat embryos.},
  author={Asher Ornoy and Shiran Bahat Rand and Noa Bischitz},
  journal={Birth defects research. Part B, Developmental and reproductive toxicology},
  year={2010},
  volume={89 2},
  pages={106-15}
}
BACKGROUND Hyperglycemia and hypoxia are well-known teratogens that may affect many animal species, including man. One of the main mechanisms of teratogenic action of both seems to be increased oxidative stress. The purpose of this study was to evaluate the hypothesis that in the developing embryo hyperglycemia also leads to hypoxia, both resulting in oxidative damage. METHODS The study was performed on 10.5-day-old rat embryos of the regular Sabra strain cultured for 28 hours in… CONTINUE READING

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The role of antioxidant enzymes and transcription factor NF-kappa B in Diabetic embryopathy in the Cohen diabetic rat model

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