Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

@article{Brasacchio2009HyperglycemiaIA,
  title={Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail},
  author={Daniella Brasacchio and Jun Okabe and Christos Tikellis and Aneta Balcerczyk and Prince George and Emma K Baker and Anna C. Calkin and Michael Brownlee and Mark Emmanuel Cooper and Assam El-Osta},
  journal={Diabetes},
  year={2009},
  volume={58},
  pages={1229 - 1236}
}
OBJECTIVE Results from the Diabetes Control Complications Trial (DCCT) and the subsequent Epidemiology of Diabetes Interventions and Complications (EDIC) Study and more recently from the U.K. Prospective Diabetes Study (UKPDS) have revealed that the deleterious end-organ effects that occurred in both conventional and more aggressively treated subjects continued to operate >5 years after the patients had returned to usual glycemic control and is interpreted as a legacy of past glycemia known as… CONTINUE READING
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UKPDS and the legacy effect.

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