Hyperglycemia, ketoacidosis and other complications of L-asparaginase in children with acute lymphoblastic leukemia.

@article{etin1994HyperglycemiaKA,
  title={Hyperglycemia, ketoacidosis and other complications of L-asparaginase in children with acute lymphoblastic leukemia.},
  author={M. Tunay Çetin and S. Hakan Yetgin and Abdurrahman Kara and A Murat Tuncer and M. G{\"u}nay and Fatma G{\"u}mr{\"u}k and Aytemiz G{\"u}rgey},
  journal={Journal of medicine},
  year={1994},
  volume={25 3-4},
  pages={219-29}
}
We show Escherichia coli derived L-asparaginase complications observed in 14 of 136 acute lymphoblastic leukemia patients during remission induction therapy according to St. Jude Children's Hospital Total XI Protocol. We observed hyperglycemia in six patients; two of them had accompanying ketoacidosis. One of the cases with ketoacidosis had peritonitis and pancreatitis. Central nervous system symptoms such as convulsions and depression with personality changes (in one case) were observed in… CONTINUE READING