Hyperglycemia, insulin resistance, impaired pancreatic β-cell function, and risk of pancreatic cancer.

Abstract

BACKGROUND Obesity and diabetes mellitus are associated with an increased risk of pancreatic cancer. These associations may be secondary to consequences of peripheral insulin resistance, pancreatic β-cell dysfunction, or hyperglycemia itself. Hemoglobin A1c (HbA1c) is a measure of hyperglycemia, whereas plasma insulin and proinsulin are markers of… (More)
DOI: 10.1093/jnci/djt123

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