Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes

@article{Vind2012HyperglycaemiaNI,
  title={Hyperglycaemia normalises insulin action on glucose metabolism but not the impaired activation of AKT and glycogen synthase in the skeletal muscle of patients with type 2 diabetes},
  author={Birgitte F. Vind and Jesper Bratz Birk and Sara Gry Vienberg and Birgitte Andersen and Henning Beck-Nielsen and J\orgen F P Wojtaszewski and Kurt H\ojlund},
  journal={Diabetologia},
  year={2012},
  volume={55},
  pages={1435-1445}
}
In type 2 diabetes, reduced insulin-stimulated glucose disposal, primarily glycogen synthesis, is associated with defective insulin activation of glycogen synthase (GS) in skeletal muscle. Hyperglycaemia may compensate for these defects, but to what extent it involves improved insulin signalling to glycogen synthesis remains to be clarified. Whole-body glucose metabolism was studied in 12 patients with type 2 diabetes, and 10 lean and 10 obese non-diabetic controls by means of indirect… CONTINUE READING

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The SNARE protein SNAP23 and the SNARE interacting protein Munc18c in human skeletal muscle are implicated in insulin sensitivity

P Boström, L Andersson, BF Vind
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