Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.

@article{Zeng2010HyperglycaemiaCR,
  title={Hyperglycaemia confers resistance to chemotherapy on breast cancer cells: the role of fatty acid synthase.},
  author={Li Zeng and Kalina M Biernacka and J M P Holly and Caroline Jarrett and Avril A. Morrison and Aric G Morgan and Z E Winters and Emily J. Foulstone and Julian P. H. Shield and Claire M. Perks},
  journal={Endocrine-related cancer},
  year={2010},
  volume={17 2},
  pages={539-51}
}
The prognosis for women with breast cancer is adversely affected by the comorbidities of obesity and diabetes mellitus (DM), which are conditions associated with elevated levels of circulating fatty acids, hyperglycaemia and hyperinsulinaemia. We investigated the effects of exposure of non-malignant and malignant human breast epithelial cells to elevated levels of fatty acids and glucose on their growth, survival and response to chemotherapeutic agents. We found that palmitate induced cell… CONTINUE READING
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