Hyperfunctioning malignant thyroid nodule in an 11-year-old girl: pathologic and molecular studies.


We identified a papillary carcinoma in an 11-year-old girl with a hyperfunctioning thyroid nodule. A met453thr mutation in TSHR was found in the nodule but not in normal thyroid tissue or in leukocytes. This case documents that this activating mutation is associated with neoplasia. 


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