Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy.

@article{Horiot1992HyperfractionationVC,
  title={Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy.},
  author={Jean Claude Horiot and Roger Le Fur and Thierry N'guyen and Ch. Chenal and Simon Schraub and Simona Alfonsi and Gianstefano Gardani and Walter van den Bogaert and S Danczak and Michel Bolla},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={1992},
  volume={25 4},
  pages={231-41}
}
EORTC protocol 22791 compared once daily fractionation (CF) of 70 Gy in 35-40 fractions in 7-8 weeks, to pure hyperfractionation (HF) of 80.5 Gy in 70 fractions in 7 weeks using 2 fractions of 1.15 Gy per day, in T2-T3 oropharyngeal carcinoma (excluding base of tongue), N0,N1 of less than 3 cm. From 1980 to 1987, 356 patients were entered. In the final… CONTINUE READING