Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase.

  title={Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase.},
  author={Dana Albert and Ilse Z{\"u}ndorf and Theo Dingermann and Walter E. M{\"u}ller and Dieter Steinhilber and Oliver Werz},
  journal={Biochemical pharmacology},
  volume={64 12},
The acylphloroglucinol derivative hyperforin is the major lipophilic constituent in the herb Hypericum perforatum (St. John's wort). The aim of the present study was to investigate if hyperforin as well as extracts of H. perforatum can suppresses the activities of 5-lipoxygenase (5-LO) and cyclooxygenases (COX), key enzymes in the formation of proinflammatory eicosanoids from arachidonic acid (AA). In freshly isolated human polymorphonuclear leukocytes stimulated with Ca(2+) ionophore A23187… CONTINUE READING


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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V • 2018
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