Hyperforin in St. John’s wort drug interactions

@article{Madabushi2006HyperforinIS,
  title={Hyperforin in St. John’s wort drug interactions},
  author={R. Madabushi and B. Frank and B. Drewelow and H. Derendorf and V. Butterweck},
  journal={European Journal of Clinical Pharmacology},
  year={2006},
  volume={62},
  pages={225-233}
}
  • R. Madabushi, B. Frank, +2 authors V. Butterweck
  • Published 2006
  • Medicine
  • European Journal of Clinical Pharmacology
  • Recently, interactions of herbal medicines with synthetic drugs came into focus of particular interest. In the past 3 years, more than 50 papers were published regarding interactions between St. John’s wort (Hypericum perforatum L.; SJW) and prescription drugs. Co-medication with SJW resulted in decreased plasma concentrations of a number of drugs including amitriptyline, cyclosporine, digoxin, indinavir, irinotecan, warfarin, phenprocoumon, alprazolam, dextrometorphane, simvastatin, and oral… CONTINUE READING
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    References

    SHOWING 1-10 OF 62 REFERENCES
    St John's wort (Hypericum perforatum): drug interactions and clinical outcomes.
    • 302
    St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.
    • 848
    • PDF
    Pharmacokinetic Interactions of Drugs with St John’s Wort
    • 201
    Potential Metabolic Interaction between St. John's Wort and Theophylline
    • 165
    St Johns wort increases expression of P-glycoprotein: implications for drug interactions.
    • 256
    Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.
    • 161
    • PDF
    Drug Interactions with St John’s Wort
    • M. Mannel
    • Medicine
    • Canadian family physician Medecin de famille canadien
    • 2001
    • 195
    Interactions between herbal medicines and prescribed drugs: a systematic review.
    • 516
    • PDF