Hyperforin content determines the magnitude of the St John's wort-cyclosporine drug interaction.

@article{Mai2004HyperforinCD,
  title={Hyperforin content determines the magnitude of the St John's wort-cyclosporine drug interaction.},
  author={Ingrid Mai and Steffen Bauer and Elke S. Perloff and Andreas Johne and Bernhard Uehleke and Bruno Dipl-Ing Frank and Klemens Budde and Ivar Roots},
  journal={Clinical pharmacology and therapeutics},
  year={2004},
  volume={76 4},
  pages={
          330-40
        }
}
OBJECTIVE Hyperforin (HYF) has been discussed as a potential cause of the reduction in the bioavailability of numerous drugs seen with St John's wort (SJW) comedication. This study compared the effects of 2 SJW preparations with high and low HYF content on the pharmacokinetics of cyclosporine (INN, ciclosporin) (CSA). METHODS In a crossover study, 10 renal transplant patients were randomized into 2 groups and received SJW extract (900 mg/d) containing low or high concentrations of HYF for 14… CONTINUE READING

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