Hyperforin-Containing Extracts of St John's Wort Fail to Alter Gene Transcription in Brain Areas Involved in HPA Axis Control in a Long-Term Treatment Regimen in Rats

Abstract

We previously showed that a methanolic extract of St John's wort (SJW) (Hypericum) and hypericin, one of its active constituents, both have delayed regulation of genes that are involved in the control of the hypothalamic–pituitary–adrenal (HPA) axis. Hyperforin, another constituent of SJW, is active in vitro and has been proposed to be the active… (More)
DOI: 10.1038/sj.npp.1300253

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