Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production.

@article{Liu1999HyperexpressionOC,
  title={Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production.},
  author={Zhong-ying Liu and Stefaan Colpaert and G D'Haens and Ahmad Kasran and Martin de Boer and P. R. Rutgeerts and Karel Geboes and Jan L Ceuppens},
  journal={Journal of immunology},
  year={1999},
  volume={163 7},
  pages={4049-57}
}
CD40 ligand (CD40L or CD154), a type II membrane protein with homology to TNF, is transiently expressed on activated T cells and known to be important for B cell Ig production and for activation and differentiation of monocytes and dendritic cells. Both Crohn's disease and ulcerative colitis are characterized by local production of cytokines such as TNF and by an influx of activated lymphocytes into inflamed mucosa. Herein, we investigated whether CD40L signaling participates in immune… CONTINUE READING

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