Hyperexpression of α-hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus

@inproceedings{Chua2013HyperexpressionO,
  title={Hyperexpression of α-hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus},
  author={Kyra Y. L. Chua and Ian R Monk and Ya-Hsun Lin and Torsten Seemann and Kellie L. Tuck and Jessica L. Porter and Justin Stepnell and Geoffrey Wallace Coombs and John K. Davies and Timothy P Stinear and Benjamin P Howden},
  booktitle={BMC Microbiology},
  year={2013}
}
The community-associated methicillin-resistant S. aureus (CA-MRSA) ST93 clone is becoming dominant in Australia and is clinically highly virulent. In addition, sepsis and skin infection models demonstrate that ST93 CA-MRSA is the most virulent global clone of S. aureus tested to date. While the determinants of virulence have been studied in other clones of CA-MRSA, the basis for hypervirulence in ST93 CA-MRSA has not been defined. Here, using a geographically and temporally dispersed collection… CONTINUE READING
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