Hyperexcitability of distal dendrites in hippocampal pyramidal cells after chronic partial deafferentation.

@article{Cai2007HyperexcitabilityOD,
  title={Hyperexcitability of distal dendrites in hippocampal pyramidal cells after chronic partial deafferentation.},
  author={Xiang Cai and Dong-sheng Wei and Sandra Gallagher and Ashish A Bagal and Yan-Ai Mei and Joseph P Y Kao and Scott M. Thompson and Cha-Min Tang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 1},
  pages={59-68}
}
Traumatic injury to the CNS results in chronic partial deafferentation of subsets of surviving neurons. Such injuries are often followed by a delayed but long-lasting period of aberrant hyperexcitability. The cellular mechanisms underlying this delayed hyperexcitability are poorly understood. We developed an in vitro model of deafferentation and reactive hyperexcitability using organotypic hippocampal slice cultures to study the underlying cellular mechanisms. One week after transection of the… CONTINUE READING

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