Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells.

  title={Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells.},
  author={Eran Meshorer and Dhananjay Yellajoshula and Eric George and Peter J. Scambler and David T. Brown and Tom Misteli},
  journal={Developmental cell},
  volume={10 1},
Differentiation of embryonic stem (ES) cells from a pluripotent to a committed state involves global changes in genome expression patterns. Gene activity is critically determined by chromatin structure and interactions of chromatin binding proteins. Here, we show that major architectural chromatin proteins are hyperdynamic and bind loosely to chromatin in ES cells. Upon differentiation, the hyperdynamic proteins become immobilized on chromatin. Hyperdynamic binding is a property of pluripotent… CONTINUE READING
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