Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension.

@article{Vorobioff1983HyperdynamicCI,
  title={Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension.},
  author={Julio D Vorobioff and James E Bredfeldt and Roberto J. Groszmann},
  journal={The American journal of physiology},
  year={1983},
  volume={244 1},
  pages={G52-7}
}
Two dissimilar hemodynamic hypotheses, the "backward flow" theory and the "forward flow" theory, have been advanced to define splanchnic hemodynamics in portal hypertension. An animal model with portal hypertension and high-grade portal-systemic shunting, the portal vein-stenotic rat, was studied to determine whether a hemodynamic picture compatible with either theory would develop. Splanchnic and systemic hemodynamics and portal-systemic shunting were measured by radioactive microsphere… CONTINUE READING