Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards.

@article{Pecia2003HyperdopaminergicMM,
  title={Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards.},
  author={Susana Peci{\~n}a and Barbara Cagniard and Kent C. Berridge and J. Wayne Aldridge and Xiaoxi Zhuang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 28},
  pages={9395-402}
}
What is the role of dopamine in natural rewards? A genetic mutant approach was taken to examine the consequences of elevated synaptic dopamine on (1) spontaneous food and water intake, (2) incentive motivation and learning to obtain a palatable sweet reward in a runway task, and (3) affective "liking" reactions elicited by the taste of sucrose. A dopamine transporter (DAT) knockdown mutation that preserves only 10% of normal DAT, and therefore causes mutant mice to have 70% elevated levels of… CONTINUE READING
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