Hyperdopaminergia and altered locomotor activity in GABAB1‐deficient mice

  title={Hyperdopaminergia and altered locomotor activity in GABAB1‐deficient mice},
  author={Claire-Marie Vacher and Martin Gassmann and Sandrine Desrayaud and Etienne Challet and Amyaouch Bradaia and Daniel Hoyer and Peter C. Waldmeier and Klemens Kaupmann and Paul P{\'e}vet and Bernhard Bettler},
  journal={Journal of Neurochemistry},
mice, which are devoid of functional GABAB receptors, consistently exhibit marked hyperlocomotion when exposed to a novel environment. Telemetry recordings now revealed that, in a familiar environment, mice display an altered pattern of circadian activity but no hyperlocomotion. This indicates that hyperlocomotion is only triggered when mice are aroused by novelty. In microdialysis experiments, mice exhibited a 2‐fold increased extracellular level of dopamine in the striatum. Following d… 

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  • B. YeeR. Keist U. Rudolph
  • Psychology, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2005
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