Hyperdiverse Gene Cluster in Snail Host Conveys Resistance to Human Schistosome Parasites

  title={Hyperdiverse Gene Cluster in Snail Host Conveys Resistance to Human Schistosome Parasites},
  author={Jacob A. Tennessen and Andre K. Theron and Melanie L. Marine and Jan-Ying Yeh and Anne Rognon and Michael S. Blouin},
  booktitle={PLoS genetics},
Schistosomiasis, a neglected global pandemic, may be curtailed by blocking transmission of the parasite via its intermediate hosts, aquatic snails. Elucidating the genetic basis of snail-schistosome interaction is a key to this strategy. Here we map a natural parasite-resistance polymorphism from a Caribbean population of the snail Biomphalaria glabrata. In independent experimental evolution lines, RAD genotyping shows that the same genomic region responds to selection for resistance to the… CONTINUE READING
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