Hypercoagulability in splenectomized thalassemic patients detected by whole-blood thromboelastometry, but not by thrombin generation in platelet-poor plasma.

@article{Tripodi2009HypercoagulabilityIS,
  title={Hypercoagulability in splenectomized thalassemic patients detected by whole-blood thromboelastometry, but not by thrombin generation in platelet-poor plasma.},
  author={Armando Tripodi and Maria Domenica Cappellini and Veena Chantarangkul and Lidia Padovan and Maria Rosaria Fasulo and Alessia Marcon and Pier Mannuccio Mannucci},
  journal={Haematologica},
  year={2009},
  volume={94 11},
  pages={1520-7}
}
BACKGROUND The mechanisms responsible for the increased thrombotic risk associated with thalassemia are still unclear. They might be related to the effects of red blood cell or endothelial cell derangements, increased numbers of platelets as well as abnormal plasma coagulation. DESIGN AND METHODS To evaluate the relative role played by cells and plasma we investigated 169 patients with thalassemia by means of thromboelastometry and thrombin generation tests. Thromboelastometry measures… CONTINUE READING