Hypercoagulability in sickle cell disease: new approaches to an old problem.

@article{Ataga2007HypercoagulabilityIS,
  title={Hypercoagulability in sickle cell disease: new approaches to an old problem.},
  author={Kenneth I Ataga and Nigel S Key},
  journal={Hematology. American Society of Hematology. Education Program},
  year={2007},
  pages={91-6}
}
Patients with sickle cell disease (SCD) exhibit high plasma levels of markers of thrombin generation, depletion of natural anticoagulant proteins, abnormal activation of the fibrinolytic system, and increased tissue factor expression, even in the non-crisis steady state. In addition, platelets and other cellular elements are chronically activated in the non… CONTINUE READING