Hypercoagulability in sickle cell disease: a curious paradox.

  title={Hypercoagulability in sickle cell disease: a curious paradox.},
  author={Kenneth I Ataga and Eugene P. Orringer},
  journal={The American journal of medicine},
  volume={115 9},
There is evidence of activation of both blood coagulation and platelets in sickle cell disease. For example, plasma samples obtained in the steady state and during painful crisis demonstrate high levels of thrombin generation, depletion of anticoagulant proteins, and abnormal activation of the fibrinolytic system. Similarly, exposure of surface markers such as CD62P and CD40L, along with increased circulating levels of thrombospondin, signal platelet activation. In addition to its effects on… CONTINUE READING