Hypercholesterolemic effect in rats of a dietary addition of the nitric oxide synthase inhibitor, L-N omega nitroarginine, by less synthesis of bile acids.

Abstract

We have previously reported that feeding rats with a diet containing 0.02% L-N omega nitroarginine (L-NNA), a specific inhibitor of nitric oxide synthase, induced hypercholesterolemia. This present study was conducted to examine the underlying mechanism for hypercholesterolemia in rats. In experiment 1, feeding a diet containing 0.02% L-NNA for 5 wk… (More)

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@article{Khedara1998HypercholesterolemicEI, title={Hypercholesterolemic effect in rats of a dietary addition of the nitric oxide synthase inhibitor, L-N omega nitroarginine, by less synthesis of bile acids.}, author={Abdelkrim Khedara and T. Goto and Jun Kayashita and N. Kato}, journal={Bioscience, biotechnology, and biochemistry}, year={1998}, volume={62 4}, pages={773-7} }