Hypercholesterolemia reduces collateral artery growth more dominantly than hyperglycemia or insulin resistance in mice.

@article{Weel2006HypercholesterolemiaRC,
  title={Hypercholesterolemia reduces collateral artery growth more dominantly than hyperglycemia or insulin resistance in mice.},
  author={Vincent van Weel and Margreet de Vries and Peter Jacobus Voshol and Robert E. Verloop and Paul H. C. Eilers and Victor W. M. van Hinsbergh and J. Hajo van Bockel and Paul H. A. Quax},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2006},
  volume={26 6},
  pages={1383-90}
}
OBJECTIVE Collateral artery development (arteriogenesis), a vital compensatory mechanism in patients with arterial obstructive disease, may be deregulated by vascular risk factors, eg, diabetes or hypercholesterolemia. Here, we compared the effects of either disturbed glucose metabolism or disturbed lipid metabolism on arteriogenesis. METHODS AND RESULTS Femoral artery occlusion was performed in streptozotocin(STZ)-treated mice, nonobese diabetic (NOD) mice, and insulin-resistant Ob/Ob mice… CONTINUE READING