Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression.

  title={Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression.},
  author={Georg Nickenig and O. Jung and Kerstin Strehlow and Oliver Zolk and Wolfgang J. Linz and Bernward A. Sch{\"o}lkens and Michael B{\"o}hm},
  journal={The American journal of physiology},
  volume={272 6 Pt 2},
Low-density lipoprotein increases the AT1-receptor gene expression in vascular smooth muscle cells. To elucidate whether elevated cholesterol serum levels upregulate the AT1 receptor and its functional response to angiotensin II in vivo, we compared 1) the vasoconstrictive effect of angiotensin II and 2) the level of expression of the vascular AT1 receptor in aortas of normocholesterolemic and hypercholesterolemic rabbits. Contraction experiments on isolated aortic rings showed that the… CONTINUE READING


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