Hypercholesterolemia impairs the myocardial angiogenic response in a swine model of chronic ischemia: role of endostatin and oxidative stress.

@article{Boodhwani2006HypercholesterolemiaIT,
  title={Hypercholesterolemia impairs the myocardial angiogenic response in a swine model of chronic ischemia: role of endostatin and oxidative stress.},
  author={Munir Boodhwani and Yasunari Nakai and Shigetoshi Mieno and Pierre Voisine and Cesario F Bianchi and Eug{\^e}nio Gonçalves de Ara{\'u}jo and Jun Feng and Keith W. Michael and Jian Li and Frank W Sellke},
  journal={The Annals of thoracic surgery},
  year={2006},
  volume={81 2},
  pages={634-41}
}
BACKGROUND Recent studies have shown that angiogenesis is regulated by a balance between activators and inhibitors. We investigated the effects of hypercholesterolemia on the functional angiogenic response and collateral formation induced by chronic myocardial ischemia and the expression of angiogenic mediators. METHODS Twelve Yucatan miniswine, fed either a normal (NORM, n = 6) or high cholesterol (HCHO, n = 6) diet for 13 weeks, underwent ameroid constrictor placement around the circumflex… CONTINUE READING

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