Hypercholesterolemia causes mechanical weakening of rabbit atheroma : local collagen loss as a prerequisite of plaque rupture.

@article{Rekhter2000HypercholesterolemiaCM,
  title={Hypercholesterolemia causes mechanical weakening of rabbit atheroma : local collagen loss as a prerequisite of plaque rupture.},
  author={Mark D. Rekhter and Gary W. Hicks and David W. Brammer and Hussein Hallak and E. Kindt and Junjie Chen and Wendy S. Rosebury and Michele K Anderson and Paul J. Kuipers and M. J. Ryan},
  journal={Circulation research},
  year={2000},
  volume={86 1},
  pages={101-8}
}
Hypercholesterolemia may render atherosclerotic plaques prone to rupture. To test this hypothesis, catheters with matrix-covered balloons were implanted into the aorta of rabbits fed standard or 0. 5% cholesterol chow (n=70). In 1 month, fibrous plaques developed around the balloon. Time-dependent accumulation of cholesteryl esters and free cholesterol was detected in the plaques of the cholesterol-fed group only. The pressure needed to rupture the plaque by balloon inflation was used as an… CONTINUE READING
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