Hypercholesterolemia blunts forearm vasorelaxation and enhances the pressor response during acute systemic hypoxia.


OBJECTIVE During hypoxia, active substances released by the endothelium play a key role in the cardiovascular and respiratory responses elicited to optimize oxygen delivery. As hypercholesterolemia is a major cause of endothelial dysfunction, it may interfere with these responses. METHODS AND RESULTS We studied cardiovascular and ventilatory responses to… (More)


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