Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children.

@article{Tolani2013HypercholesterolemiaAR,
  title={Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children.},
  author={Sonia Tolani and Tamara A. Pagler and Andrew J. Murphy and Andrea E. Bochem and Sandra Abramowicz and Carrie B. Welch and Prabhakara R Nagareddy and Steve Holleran and G. K. Hovingh and Jan A. Kuivenhoven and Alan R. Tall},
  journal={Atherosclerosis},
  year={2013},
  volume={229 1},
  pages={
          79-85
        }
}
Previous studies have shown that mice with defects in cellular cholesterol efflux show hematopoietic stem cell (HSPC) and myeloid proliferation, contributing to atherogenesis. We hypothesized that the combination of hypercholesterolemia and defective cholesterol efflux would promote HSPC expansion and leukocytosis more prominently than either alone. We crossed Ldlr(-/-) with Apoa1(-/-) mice and found that compared to Ldlr(-/-) mice, Ldlr(-/-)/Apoa1(+/-) mice, with similar LDL-cholesterol levels… CONTINUE READING

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