Hypercholesterolemia and atherosclerosis in low density lipoprotein receptor mutant rats.

@article{Asahina2012HypercholesterolemiaAA,
  title={Hypercholesterolemia and atherosclerosis in low density lipoprotein receptor mutant rats.},
  author={Makoto Asahina and Tomoji Mashimo and Michiyasu Takeyama and Ryuichi Tozawa and Tadatoshi Hashimoto and Akiko Takizawa and Masatsugu Ueda and Toshihiro Aoto and Takashi Kuramoto and Tadao Serikawa},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={418 3},
  pages={553-8}
}
To establish low density lipoprotein receptor (LDLR) mutant rats as a hypercholesterolemia and atherosclerosis model, we screened the rat LDLR gene for mutations using an N-ethyl-N-nitrosourea mutagenesis archive of rat gene data, and identified five mutations in its introns and one missense mutation (478T>A) in exon 4. The C160S mutation was located in the ligand binding domain of LDLR and was revealed to be equivalent to mutations (C160Y/G) identified in human familial hypercholesterolemia… CONTINUE READING
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