Hypercholesterolemia aggravates radiocontrast nephrotoxicity: protective role of L-arginine.

@article{Andrade1998HypercholesterolemiaAR,
  title={Hypercholesterolemia aggravates radiocontrast nephrotoxicity: protective role of L-arginine.},
  author={L E Andrade and Simone Becho Campos and Ant{\^o}nio Carlos Seguro},
  journal={Kidney international},
  year={1998},
  volume={53 6},
  pages={1736-42}
}
It is well known that the radiocontrast-induced ARF depends on risk factors often associated with compromised renal circulation. Since studies have shown that endothelium-dependent vasodilation is impaired in hypercholesterolemia (HC), we studied the effect of radiocontrast (RC) administration (6 ml/kg body wt, via femoral artery) in salt-depleted rats that were kept on a normal cholesterol (NC) or HC diet (4% cholesterol and 1% cholic acid). Inulin clearance (CIn, ml/min/100 g body wt), renal… CONTINUE READING