Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κB-dependent mechanism.

@article{Contreras2012HypercapnicAA,
  title={Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κB-dependent mechanism.},
  author={Maya M B Contreras and Bilal Ansari and Gerard F Curley and Brendan D. Higgins and Patrick Hassett and Daniel O'Toole and John G. Laffey},
  journal={Critical care medicine},
  year={2012},
  volume={40 9},
  pages={2622-30}
}
OBJECTIVES Hypercapnic acidosis protects against ventilation-induced lung injury. We wished to determine whether the beneficial effects of hypercapnic acidosis in reducing stretch-induced injury were mediated via inhibition of nuclear factor-κB, a key transcriptional regulator in inflammation, injury, and repair. DESIGN Prospective randomized animal study. SETTING University research laboratory. SUBJECTS Adult male Sprague-Dawley rats. INTERVENTIONS In separate experimental series, the… CONTINUE READING
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