Hypercalciuria in a new rat model of hyperprolactinemia.

  title={Hypercalciuria in a new rat model of hyperprolactinemia.},
  author={Robert A. Adler and Maureen E Farrell and W P Deiss and Richard J. Krieg and Robert M. Macleod},
  journal={Metabolism: clinical and experimental},
  volume={40 3},
Hypercalciuria has been reported in rats with mild hyperprolactinemia due to implantation of anterior pituitary glands under the kidney capsule and in rats bearing transplantable tumors that secrete large amounts of prolactin (PRL) and growth hormone (GH). We studied Buffalo rats implanted subcutaneously with the new MMQ pituitary tumor line that secretes only PRL. Urinary calcium excretion increased as the tumors grew. Three weeks after tumor implantation in female rats, the urinary calcium… CONTINUE READING