• Medicine
  • Published in
    Nouvelle revue francaise d…
    1985

Hypercalcemia in chronic myelogenous leukemia: evidence for excessive parathyroid hormone secretion.

@article{Molho1985HypercalcemiaIC,
  title={Hypercalcemia in chronic myelogenous leukemia: evidence for excessive parathyroid hormone secretion.},
  author={P. Molho and M. J. Grange and Jean Gueris and Jean Jacques Ballet and Jean Luc Wautier and G{\'e}rard Tobelem and Jacques Philippe Caen},
  journal={Nouvelle revue francaise d'hematologie},
  year={1985},
  volume={27 3},
  pages={
          189-92
        }
}
Hypercalcemia was associated with osteolytic bone lesions in a 60-year-old woman with chronic myelogenous leukemia in the accelerated phase. Using highly specific antisera to parathyroid hormone, radioimmunoassays disclosed elevated levels of carboxyl-terminal (53-84) and intermediate (44-68) fragments. In addition, concomitant variations of serum calcium level and leukocyte counts, increased urinary c-AMP excretion, morphological integrity of parathyroid glands, and absence of bone resorbing… CONTINUE READING