Hyperbilirubinemia Diminishes Respiratory Drive in a Rat Pup Model

  title={Hyperbilirubinemia Diminishes Respiratory Drive in a Rat Pup Model},
  author={Oded Mesner and Martha J. Miller and Sabine C. Iben and K. Suria Prabha and Catherine A. Mayer and Musa A. Haxhiu and Richard J. Martin},
  journal={Pediatric Research},
Although apnea is common in premature babies, there is a paucity of information concerning the pathophysiologic basis of these episodes and their relationship to other perinatal conditions such as hyperbilirubinemia. Unconjugated hyperbilirubinemia in premature infants, even in moderately high levels, may cause encephalopathy affecting brainstem functions and has been linked to increased incidence of apnea in these infants. Thus, there is a need to clarify mechanisms by which bilirubin may… CONTINUE READING


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